Pharmacogenetics in oncology

Pharmacogenetics for oncology practice.

Pharmacogenetics in oncology: a promising field.

Pharmacogenetics is a rapidly developing field, especially in oncology. In the most ideal situation pharmacogenetics will allow oncologists to individualize therapy based on patients' individual germline genetic test results. This can help to improve efficacy, reduce toxicity and predict non-responders in a way that alternative therapy can be chosen or individual dose adjustments can be made. M...

Pharmacogenetics and pharmacogenomics in oncology therapeutic antibody development.

Pharmacogenetics and pharmacogenomics are keys to the success of personalized medicine, prescribing drugs based on a patient's individual genetic and biological profile. In this review, we will focus on the application of pharmacogenetics and pharmacogenomics in developing monoclonal antibody (MAb) therapeutics in oncology. The significance of pharmacogenomics in MAb therapeutics is highlighted...

Brain mapping in Neurosurgical oncology

After the introduction of MRI, new modalities facilitated the procedure of surgical planning to achieve the microsurgical goal and improve prognosis and quality of life in patients. Despite the variable applications of preoperative and intraoperative mapping and monitoring systems, several limitations and concerns are reported for every modality as well. In this issue of the IrJNS, we are delig...

Pharmacogenetics in Practice Pharmacogenetics in Cardiology: Forays into Modern Practice

When one discusses pharmacogenetics in cardiology practice, it is almost obligatory to discuss clopidogrel. Clopidogrel is an antiplatelet used for acute coronary syndrome (ACS), percutaneous coronary intervention (PCI) with stenting, and as secondary stroke prevention in patients with aspirin allergy, among other indications. Clopidogrel is a prodrug that must be metabolized through the cytoch...